Un portrait d’Édouard Laboulaye (1811-1883)1

Dmd057893 1811..1819

We have previously established an in silico classification method (“CPathPred”) to predict the major clearance pathways of drugs based on an empirical decision with only four physicochemical descriptors—charge, molecular weight, octanol-water distribution coefficient, and protein unbound fraction in plasma—using a rectangular method. In this study, we attempted to improve the prediction perform...

Portrait

Born in 1944, I grew up in a world in which polio was both a gripping fear and real threat. Then in a matter of a few years-polio was eradicated by a vaccine developed by Jonas Salk. Later I learned that Salk's efforts were built on pioneering work of many others, including John Enders, Thomas Weller and Frederick Robbins (Nobelists, 1954), and David Bodian, who pioneered studies of polio patho...

James Young Simpson (1811?1870)

James Young Simpson was one of the first obstetricians to administer anesthesia during childbirth in nineteenth century Scotland. Before his work in the 1800s, physicians had few ways to reduce the pain of childbirth. Simpson experimented with the use of ether and chloroform, both gaseous chemicals, to temporarily relieve pain. He found that those chemicals both successfully inhibited the pain ...

Un petit cercle, un grand exemple (دایره‌ای کوچک، سرمشقی بزرگ )

نام هانری کربن با دو دایره گره خورده است: دایرة ارانوس و دایرة تهران؛ دایره‌هایی که مطابق منظر کربن، می‌توان آنها را به‌درستی رمزی و مثالی خواند. این مقاله به دایرة تهران اختصاص دارد، دایره‌ای تحقیقی که با حضور اندیشمندانی چند، و با محوریت دو شخصیت از شرق و غرب، علامه سید محمد حسین طباطبایی و هانری کربن، شکل می‌گرفت. برغم همه مشکلات فنی و فیزیکی ارتباط کلامی، این دو مرد، به خوبی با یکدیگر «مقاب...

Google Portrait